Here Professor N. Ruparelia discusses the complications associated with acute plaque rupture with progressive coronary artery disease and the aims of therapy.
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what sort of complications would be associated? So coronary artery disease itself is benign if asymptomatic. However, the risk of coronary disease is the risk of what we call plaque rupture, or when some of the furring suddenly becomes unstable and causes a blockage of is a blockage of an artery. Now that in the heart would manifest itself as symptoms at rest with symptoms for example associated with this for example breathlessness, sweatiness and that would mean that a patient would be possibly suffering from a heart attack or an acute blockage of an artery. The treatment of that is calling for help emergently and we often operate on patients to restore blood flow to those arteries as quickly as possible. Plaque rupture in other parts of the body, for example in the brain, may manifest itself as a stroke and indeed can also affect legs with acute limb ischemia and even organs potentially, but that is rarer. So the manifestation of acute complications are to do with acute vascular injury associated with plaque rupture. The aims of therapy, risk factor modification for example, is all aimed at trying to reduce the risk of this occurrence.
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