How does smoking increase the risk of cardiovascular disease?

How does smoking increase your risk of cardiovascular disease? I mean of course there's lots of toxins within cigarettes and a lot of those toxins have an adverse effect on multiple systems in the body be it your GI system, of course your respiratory system where the smoke is initially inhaled and on the cardiovascular system because those noxious chemicals again damage the lining of the vessels vessels and make it more likely for plaque to build up in them. So you know, I work at Imperial where we have a primary angioplasty centre where people come in with heart attacks and you know when you ask time and time again in the people who are under 50 and even under 40 year olds who come in with heart attacks time and again the common theme is that they are a smoker and it might might not even be that they're a heavy smoker smoking 30 a day it might be that they're a light smoker but in some people of course who are more prone the chemicals again the noxious chemicals will damage or disrupt the endothelial lining making it much more likely for you know plaque to stick on or even if it's not significant plaque disease it might be just the clot that sticks on and to the damaged endothelial lining and causes heart attacks so you know very clear association between smoking and chronic autistics.