How do you know if you will benefit from Statin therapy?

Dr. Kennegan-Ireham, which patients would benefit from statin therapy? So patients who are traditionally at the moment in the UK, what we're using is risk scores, which is absolutely reasonable. They give you a general idea of your mortality, your risk of mortality over a 10-year period. So if you put your numbers and details and your LDL cholesterol levels, total cholesterol divided by HTL cholesterol levels, plus your weight, your smoking history, your family history, all into a risk score, you come out with a number which gives you your percentage chance of having an event over the next 10 years. And if that number's over 10%, then that's what we currently use in the UK to guide statin therapy. Now in some circumstances, it can be difficult. There are obviously patients who are unkeen on taking statins for one reason or another, or patients in whom they've tried statins and haven't necessarily had an easy ride, have had some minor side effects and things like that. And so getting further information about their risk profile may be more valuable, and that's where you think about doing things like a calcium score. But a risk calculator is what the majority of people use to begin with, and I think that's perfectly reasonable. As I say, cardiologists, like myself, will have a gut feeling about some patients where you'd want to perhaps do something further if the risk percentage it came up with was not significant or came up with a number that was, let's say, 9%. If your risk of an event over the next 10 years was 9% rather than 10%, would you really be happy to go without therapy that could really change your outcome? And so there'll be people who we use our judgment on, but on the balance, we tend to use risk scores. Thank you.