What is peripheral arterial disease?

So peripheral tear disease is a pathology which affects the lower limbs and essentially can be monolateral or bilateral in many cases and of course it has different stages correlated to the amount of the disease. So the disease means that the vessels are stenose, they are narrowed because of different pathologies, could be diabetes, could be calcium, could be any significant narrowing of the arteries which are causing starving of blood flow to the muscles at the level of the calves or at the level of the foot. And the peripheral arterial disease is very common, but it's divided in two big groups. Whenever it's below the level of critical limb ischemia or whatever is critical limb ischemia. I'm talking about a group of clodicans, that means some people who can't walk very far because of, you know, cramps at the level of the calves, and the cramps can occur in a different length of walking. For example, people can develop cramps after 200 yards or 100 yards, or people can even develop cramps after a few yards, 50 or 20 yards. So of course, you know, the symptoms are very different. Of course, also the quality of life is affected differently. When we're talking instead of critical limb ischemia, we have three different stages. One is what is called the rest pain. So when the patient lies down and experience, especially during the night cramps, which many times lead the patient not to be able to sleep in a normal position. Many times the patient come after months they're sleeping on a chair just to try to help with gravity, the lack of blood flow supply to the foot, or even can be the last stages of critical limb ischemia tissue loss which could be minor or could be even major so essentially it can be a small ulcer at the level of the fifth toe or could be a massive necrosis at the level of the forefoot. In these cases you know whatever is critical limb ischemia is very important to treat the patients in a correct way but especially in a correct time manner because time is tissue.