Benefits and risk of Metformin.

Issues could be like, some people are intolerant to metformin, metformin has side effects, GI side effects, they can feel nausea, vomiting or some people have diarrhea as well. So that's That's why we start with, initially it used to be 500 milligram, then it gradually because nowadays we try to intensify very, at early stage now, so it's not like we wait for one week and then we wait for another week, 500 BB, then we intensify. But we start here at 500 milligram twice a day and see if they don't tolerate, then we We also try modified release. If they don't, then we have to use other oral agent.