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How Orlistat pills work.
Health Impacts and MechanismsAdaptation and Changebad-smelling gasoffensive diarrheaOrlistatintestine

How Orlistat pills work.

This video discusses the way Orlistat inhibits the enzyme lipase in the overall function of inducing fat malabsorption. However, what is mentioned is that the change in dietary behaviour due to the unpleasant side effects of Orlistat are what assist with the most part of weight loss.

Transcript (auto-generated)

This transcript was generated automatically and may contain errors.

How do Olistat pills work? Olistat is a drug that basically inhibits an enzyme in the intestine called lipase and the function of lipase is to basically break down ingested fat into smaller molecules which can then get absorbed through the intestinal surface. Now what Olistat does, it basically stops this enzyme from functioning and that stops the fat from being absorbed. So basically this drug causes fat malabsorption. So if anybody eats anything fatty, the fat will not get absorbed and it basically comes out in a bowel movement. But interestingly, it's not actually the reduced absorption of fat that leads to weight loss with Orlistat, but actually it's the behavioral change that Orlistat triggers. Because clearly if you're not absorbing fat and it's coming out in your bowels, the actual stools will be fairly unpleasant, very often smelly, offensive diarrhea, and quite leaky with bad-smelling gas. So in fact, it is those side effects of the drug that actually stops people from eating fatty meals, which in turn can lead to mild weight loss. At best, with oily stat weight loss, we see is about two to three kilograms at best.

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