What is Type 1 Diabetes?
Type 1 Diabetes Mellitus (T1DM), also known simply as type 1 diabetes, is life-long condition affecting the bodies’ ability to control the level of blood sugar. If not controlled, this can affect various part of your bodies, such as your eyes, your kidneys and nerves and put you at greater risk of getting heart attacks and strokes. In type 1 diabetes, your pancreas are damaged by the body’s own immune system and therefore don’t produce any insulin.
What is the Pancreas Gland?
The pancreas is an organ in the human body that produces various hormones, or in other words, chemical messengers, that are released and circulate around the body and communicate with other organs and muscles to carry out functions. One such hormone the pancreas produces is insulin, which allows the body to control the level of the blood sugar. The level of sugar in a person’s blood is tightly regulated to make sure the body can undertake everyday functions and also avoid the damaging effects of high blood sugar. In type 1 diabetes, the pancreas is damaged by the bodies’ own immune system.
The result of this is that the pancreas can no longer produce enough insulin to control the blood sugar level. This leads to long-standing increase in blood sugar levels which increases the risk of developing cardiovascular disease and can directly damage the blood vessels and nerves, in particular, those supplying the kidneys and eyes (see Complications).
What is insulin?
Insulin also allows the body to use the sugar in blood, without it there is reduced uptake of sugar intake the organs and muscles. Additionally, the absence of insulin in the blood stream triggers the body to enter starvation mode and means that the body starts to produce an energy substitute known as ketones. If these ketones accumulate in the presence of dehydration this can be dangerous (see Complications).
The number of people developing type 1 diabetes has increased over the last 30 years. Type 1 diabetes is caused by the immune system, designed for fighting infections, attacking the cells in the pancreas itself.
This is known as auto-immune (meaning the immune system attacking part of the body) mediated destruction. We know this is the case as the majority of people with type 1 diabetes have detectable antibodies (immune cells) in their blood that specifically target parts of the pancreatic make up. The pancreas is an organ in the human body that produces various hormones in the body. One such hormone produced by the pancreas is Insulin and it is produced by cells in the pancreas called beta cells. The cells in the pancreas that produce insulin are known as beta cells. These cells are gradually depleted or destroyed until there is no longer enough insulin to control the blood sugar level. When considering what causes a disease, there is an interplay between someone’s genetics and what they are exposed to in life. The genetic code involved writes the script for the molecules that present bugs and infections to the immune system. People with type 1 diabetes have part of genetic code that writes script for antibodies that target parts of their own pancreas. Some of the environmental factors and key exposures thought to be involved in the development of type 1 diabetes include certain viruses (enteroviruses) and dietary factors (vitamin D) – however the mechanism behind this is complex. Other risk factors include infections whilst in womb, infections as a young baby and dietary deficiencies as well as an increased body weight as a child.
The long-term aim of medical management is to mirror the function of the pancreas by giving insulin therapy. This is important to avoid the damaging effects of elevated blood sugar levels whilst also preventing the body going into starvation mode and producing ketones. Furthermore, close monitoring is required to prevent over-treatment with insulin causing a low blood sugar which can be life threatening. Insulin therapy can be given using a range of strategies. The treatment plan used will be decided jointly by yourself and the doctor looking after your care. A common strategy includes an injection of a long-acting background insulin once per day in addition to a quick-acting insulin injection with meals – this is commonly known as the basal-bolus strategy. Furthermore, insulin can be delivered by an insulin pump. This is an electronic medical device with a delivery system in the form of a plastic tube (known as a cannula) that administers insulin into the fat beneath the skin. It is connected to a pack that is worn externally. The main advantage of this is that you don’t have to inject into your skin as often. However, the downsides include that it can be tricky to familiarise yourself with the device and the need to continually wear it.
Throughout the day blood sugar levels are measuring using a finger-prick blood test known as capillary glucose testing (CBGs). Blood glucose levels are monitored in the long-term using HbA1c levels – this represents an average level. Rarely, transplantation of a working pancreas can be a treatment for type 1 diabetes. This is usually performed at the same time as a kidney transplant for someone who has developed severe complications of their diabetes. Please see Treatment and Continued Care
What tests will I undergo to diagnose type 1 diabetes?
The diagnosis of type 1 diabetes is made on the grounds of a fitting picture of the condition alongside blood tests – the diagnosis is made by a specialist Endocrinologist.
1. The first investigation undertaken in the majority of people will be to test the level of blood glucose (sugar). This can be taken after a person has been instructed not to eat (fasting test) or in the form of a glucose tolerance which involves a blood test 2 hours after consuming a set amount of sugar in the form of a drink.
2. Another investigation is measuring a marker in your blood known as HbA1c can indicate the average level of blood glucose over 60 days and both helps in the diagnosis and monitoring of the condition.
3. The doctor might also measure the amount of known antibodies against antigens in the pancreas is commonplace with many people being tested for antibodies against glutamic acid decarboxylase, tyrosine-phosphate-like molecule or insulin.
4. Furthermore, the level of insulin in addition to a breakdown molecule of insulin known as c-peptide can also help to diagnose diabetes. If these antibodies are present, it supports the diagnosis of diabetes. However, their absence does not rule out diabetes and a person can still be diagnosed with type 1 diabetes.
Prognosis – Will I be able to get better if I have type 1 diabetes?
Type 1 diabetes is a life-long illness, sometime referred to as a chronic disease. There is no single cure for the condition. However, it has been proven that close control of blood sugar levels and certain medications helps to avoid developing complications of diabetes and improve survival in the long term. These complications are detailed in the Complications
How common is Type 1 Diabetes?
Type 1 diabetes accounts for up to 10% of all causes of diabetes. The most common time for developing (or diagnosing) type 1 diabetes is around 5 – 14 years of age and it is the most common type of diabetes seen in young people. It is slightly more common in males in comparison to females. The number of people with type 1 diabetes varies around the world for example, it affects 60 per 100,000 people in Finland whilst as few as 0.1 per 100,000 people in India, China or Venezuela. In the UK type 1 diabetes affects around 400,000 people. Generally, the number of people developing type 1 diabetes is generally increasing across the world and it is thought to affect over 1 million people worldwide.
People will suffer from urinating more often as the increased level of sugar in the blood draws water into the urine.
People experience increased thirst to compensate for the water they lose in the urine.
From the body's inability to store sugar from food properly.
From the body's inability to store sugar from food properly.
If the body enters starvation mode it may use fat as an energy source producing ketones which can be smelt on the breath.
Caused by over-treatment of insulin which if severe can cause the body to “shut-down” and enter a decreased state of consciousness or coma
This is when there is not enough insulin in the body and ketones (energy substrates) are produced instead. The productions of ketones in the presence of dehydration causes the blood to become increasing acidic. If severe and untreated this can cause the organs to fail and ultimately be fatal.
The term used to describe the gradual damage caused to the back of the eye (retina) which allows people to see.
Diabetic nephropathy relates to the damage caused to the kidneys which can ultimately cause the kidneys to fail and need for artificial dialysis to take over the function of the kidneys.
Damage to nerves, known as diabetic neuropathy, can lead to a reduction in function of the nerves leading to numbness of the skin or persistent (neuropathic) pain.