What causes Peripheral Arterial Disease to Develop?

So the causes of peripheral arterial disease are multiple and something that is correlated to diabetes, of course, especially in the last stages of peripheral arterial disease, which is called, again, critical limb ischemia. There's of course the smoking, which is a part of the possible pathological factors. of course, the hypercholesterolemia, hypertension, and also there's a little bit of genetic component sometimes, which is sometimes very also difficult to understand. So there are, for example, cases of pathologies of the connective tissues, like could be Ehlers-Danlos syndrome or, you know, could be something in the blood like antiphospholipid syndrome or lupus erythematosus Systemicus, which could bring some more advanced occlusion of the vessels, which are actually not filled by plugs, like in the case of diabetes, where calcium mixed to lipids occlude the vessels, but it's just a sort of a degeneration of the tissue of the vessel itself, so which can be even more severe.