What are the risks and benefits of SGLT-2 inhibitors.

The major risk would be a fatal and life-threatening risk of euglycemic ketosis, in which the blood sugar level is normal, but the patients can experience serious side effects from it. In experienced patients sometimes have required admission to intensive care. So robust patient selection like any other treatment is crucial. Patients who have a decreased oral intake of food or patients who are dehydrated or have a low beta cell reserve, they're at a higher risk of developing euglycemic ketosis. And when we talk about benefits, clearly the benefits from SGLT2 treatment would be a reduction in HbA1c and also management of blood pressure control, renal protection, and cardiovascular protection in patients with diabetes.